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In addition, the reduction in Dox-induced apoptosis by Ex4a-specific siRNAs was cancelled by concomitant compelled overexpression of Ex4a(+)WT1 isoform. These success indicated that endogenous Ex4a(+)WT1 had a physiological function to market apoptosis.DiscussionThe WT1 gene produces 4 key isoforms by alternative splicing of exon 5 (17AA) and exon nine (KTS). All four main isoforms are overexpress
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