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Se endothelial exocytosis (Fig. 3B). Taken together, these data suggest that C5a induces limited endothelial exocytosis, but that the effects are additive with that of antibody.Antibody to HLA Activates Release of VWF Through N-EthylmaleimideSensitive Factor (NSF) and Calcium Signaling. In theory, antibodyBecause specific classes of antibody can activate complement, we were interested in the effec
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Fluenza infection are incompletely resolved. One study concluded that induction of the inflammasome pathway is required for maximal production of antiviral serum IgM and IgG and intranasal IgA (64), while studies in IL-1R-/- mice revealed a distinct deficit in influenza-specific IgM but not IgG or IgA secretion following influenza infection ((65) and Waffarn Baumgarth, unpubl.). Others failed to
1
Se endothelial exocytosis (Fig. 3B). Taken together, these data suggest that C5a induces limited endothelial exocytosis, but that the effects are additive with that of antibody.Antibody to HLA Activates Release of VWF Through N-EthylmaleimideSensitive Factor (NSF) and Calcium Signaling. In theory, antibodyBecause specific classes of antibody can activate complement, we were interested in the effec
1
Se endothelial exocytosis (Fig. 3B). Taken together, these data suggest that C5a induces limited endothelial exocytosis, but that the effects are additive with that of antibody.Antibody to HLA Activates Release of VWF Through N-EthylmaleimideSensitive Factor (NSF) and Calcium Signaling. In theory, antibodyBecause specific classes of antibody can activate complement, we were interested in the effec
1
Se endothelial exocytosis (Fig. 3B). Taken together, these data suggest that C5a induces limited endothelial exocytosis, but that the effects are additive with that of antibody.Antibody to HLA Activates Release of VWF Through N-EthylmaleimideSensitive Factor (NSF) and Calcium Signaling. In theory, antibodyBecause specific classes of antibody can activate complement, we were interested in the effec
1
Intact TAT sequence but scrambled NSF domain) has no effect upon exocytosis. Furthermore, the TAT-NSF peptide has no effect upon surface HLA expression (SI Fig. 10). These data show that antibody induces release of VWF through an NSF-dependent pathway. Calcium plays a critical role in exocytic pathways (17). To examine whether calcium signaling is required for antibody triggered release of VWF, we
1
Se endothelial exocytosis (Fig. 3B). Taken together, these data suggest that C5a induces limited endothelial exocytosis, but that the effects are additive with that of antibody.Antibody to HLA Activates Release of VWF Through N-EthylmaleimideSensitive Factor (NSF) and Calcium Signaling. In theory, antibodyBecause specific classes of antibody can activate complement, we were interested in the effec
1
To cross-link the monovalent Fab. Fab alone does not cause VWF release, but adding goat antibody to cross-link the Fab fragment increases exocytosis (Fig. 5B). This finding suggests that antibody to HLA activates endothelial exocytosis by cross-linking HLA class I.Antibody to HLA Activates Leukocyte Adherence to Endothelial Cells.clustering of HLA molecules, we compared several fragments ofWe next
1
Intact TAT sequence but scrambled NSF domain) has no effect upon exocytosis. Furthermore, the TAT-NSF peptide has no effect upon surface HLA expression (SI Fig. 10). These data show that antibody induces release of VWF through an NSF-dependent pathway. Calcium plays a critical role in exocytic pathways (17). To examine whether calcium signaling is required for antibody triggered release of VWF, we
1
Fluenza infection are incompletely resolved. One study concluded that induction of the inflammasome pathway is required for maximal production of antiviral serum IgM and IgG and intranasal IgA (64), while studies in IL-1R-/- mice revealed a distinct deficit in influenza-specific IgM but not IgG or IgA secretion following influenza infection ((65) and Waffarn Baumgarth, unpubl.). Others failed to
1
Se endothelial exocytosis (Fig. 3B). Taken together, these data suggest that C5a induces limited endothelial exocytosis, but that the effects are additive with that of antibody.Antibody to HLA Activates Release of VWF Through N-EthylmaleimideSensitive Factor (NSF) and Calcium Signaling. In theory, antibodyBecause specific classes of antibody can activate complement, we were interested in the effec