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Internal carotid artery endarterectomy using synthetic polytetrafluoroethylene (PTFE) patch (W.L.Gore Associates, Newark, Delaware) under general anesthesia. Shunt for maintaining brain blood flow was not used in these operations. After endarterectomy, carotid plaque was carefully placed in 10 buffered formalin for further processing. Postoperatively, patients were normally recovered and left h
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Internal carotid artery endarterectomy using synthetic polytetrafluoroethylene (PTFE) patch (W.L.Gore Associates, Newark, Delaware) under general anesthesia. Shunt for maintaining brain blood flow was not used in these operations. After endarterectomy, carotid plaque was carefully placed in 10 buffered formalin for further processing. Postoperatively, patients were normally recovered and left h
1
Internal carotid artery endarterectomy using synthetic polytetrafluoroethylene (PTFE) patch (W.L.Gore Associates, Newark, Delaware) under general anesthesia. Shunt for maintaining brain blood flow was not used in these operations. After endarterectomy, carotid plaque was carefully placed in 10 buffered formalin for further processing. Postoperatively, patients were normally recovered and left h
1
Internal carotid artery endarterectomy using synthetic polytetrafluoroethylene (PTFE) patch (W.L.Gore Associates, Newark, Delaware) under general anesthesia. Shunt for maintaining brain blood flow was not used in these operations. After endarterectomy, carotid plaque was carefully placed in 10 buffered formalin for further processing. Postoperatively, patients were normally recovered and left h
1
Samples were stored in aliquots at -80 until analysis. For hematological determinations, EDTA tubes were used and measurements were performed immediately. White blood cells (WBC), platelets (PLT), hematocrit (HCT), and glycosylated hemoglobin (HbA1c) were automatically measured in hematological analyzer (Beckman Coulter LH 750). Thrombosis related parameters as fibrinogen, antithrombin III, prote
1
Samples were stored in aliquots at -80 until analysis. For hematological determinations, EDTA tubes were used and measurements were performed immediately. White blood cells (WBC), platelets (PLT), hematocrit (HCT), and glycosylated hemoglobin (HbA1c) were automatically measured in hematological analyzer (Beckman Coulter LH 750). Thrombosis related parameters as fibrinogen, antithrombin III, prote
1
Samples were stored in aliquots at -80 until analysis. For hematological determinations, EDTA tubes were used and measurements were performed immediately. White blood cells (WBC), platelets (PLT), hematocrit (HCT), and glycosylated hemoglobin (HbA1c) were automatically measured in hematological analyzer (Beckman Coulter LH 750). Thrombosis related parameters as fibrinogen, antithrombin III, prote
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M/content/13/1/Page 6 ofAHThCHTh**TXNIP -actinBTDTTXNIP -actin***Figure 3 TXNIP overexpression in ATC HTh74 and T238 cells attenuates glucose uptake. HTh74 and T238 cells were transduced with retrovirus encoding human TXNIP or vector control as well as a selectable antibiotic resistance marker, and stable pools were generated under antibiotic selection. Western blot analysis of whole cell lysates
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Ated development of high grade and invasive tumors by 4 weeks compared to controlswith wild-type expression, however, controls eventually succumb to tumor development and TXNIP expression in these tumors has been downregulated by other mechanisms [24]. In the orthotopic ATC model, TXNIP overexpression also led to a significant reduction in pulmonary metastatic burden. Inhibition of metastasis con
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Our prior studies using HTh74 cells in the orthotopic murine thyroid cancer model system, we have observed that the in vivo growth rates are slower compared to other thyroid cancer cell lines (84 days to achieve 100 mm3 tumors compared with 28?5 days in other ATC cell lines). It is possible that if our study had been temporally extended, the trend in tumor volume attenuation in the TXNIP-overexpre
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Our prior studies using HTh74 cells in the orthotopic murine thyroid cancer model system, we have observed that the in vivo growth rates are slower compared to other thyroid cancer cell lines (84 days to achieve 100 mm3 tumors compared with 28?5 days in other ATC cell lines). It is possible that if our study had been temporally extended, the trend in tumor volume attenuation in the TXNIP-overexpre
1
Our prior studies using HTh74 cells in the orthotopic murine thyroid cancer model system, we have observed that the in vivo growth rates are slower compared to other thyroid cancer cell lines (84 days to achieve 100 mm3 tumors compared with 28?5 days in other ATC cell lines). It is possible that if our study had been temporally extended, the trend in tumor volume attenuation in the TXNIP-overexpre